高胆红素血症对血清肿瘤标志物测定的影响

目的 分析高胆红素血症对肿瘤标志物Ca199、Ca 242、Ca125、Ca153和CEA检测的影响.方法 对 56例胆囊胆管良性疾病、12例肝硬化、9例肝炎合并高胆红素血症患者进行Ca199、Ca242、Ca125、Ca153 和CEA血清浓度检测.结果 在良性胆囊胆管疾病中,Ca199的假阳性率最高,在高胆红素血症的良性疾病中,Ca199的假阳性率为53.25%,治疗后血清胆红素下降,Ca199也明显下降 ,Ca199的假阳性率与引起高胆红素血症的病因无关.结论 高胆红素血症对肿瘤标志物Ca199检测影响最明显,胆囊、胆管良恶性疾病鉴别时,以Ca242、Ca125、Ca153和CEA检测为佳.

Analysis of serum tumor markers in patients with hyperbilirubinemia

Objective To analyze the serum tumor markers in patients with hyperbilirubinemia. Methods The serum Ca199,Ca242,Ca125,Ca153 and CEA were assayed in 77 patients with hyperbilirubinemia. Of which 56 was benign gallbladder diseases , 12 cirrhosis and 10 hepatitis patients. Results The false positive rate of the serum Ca199 in patients with benign gallbladder diseases was the highest. For all patients, the false positive rate for Ca199 reached to 53.25 %. Conclusion The serum Ca199 was rather high in hyperbilirubinemia, For differentiating from benign or malignancy in the diseases of the bile duct and gallbladder other tumor markers such as Ca242 ,Ca125 ,Ca153 and CEA might be tried to test their specificity,