Osteosarcoma and acute myeloblastic leukemia after therapy for childhood Hodgkin disease - A case report

A child diagnosed with Stage IVB Hodgkin disease at nine and one-half years of age subsequently developed osteosarcoma and acute myelogenous leukemia ten years after her initial diagnosis. She received multiple courses of radiotherapy and several single chemotherapeutic agents for her Hodgkin disease. Therapy-induced multiple malignancies and intrinsic predisposition to carcinogenesis in this case is discussed.