| 维拉帕米对实验性高血压糖尿病性心肌病大鼠心肌的保护作用 |
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| 引用本文： | 吴立群 陈达光. 维拉帕米对实验性高血压糖尿病性心肌病大鼠心肌的保护作用[J]. 中国药理学与毒理学杂志, 1993, 7(1): 23-26 |
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| 作者姓名： | 吴立群 陈达光 |
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| 作者单位： | 南京铁道医学院心血管研究室，南京铁道医学院心血管研究室，南京铁道医学院心血管研究室 南京 210009，南京 210009 福建医科大学第一附属医院，福州 390005，南京 210009 |
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| 摘 要： | 肾性高血压糖尿病大鼠ig维拉帕米(Ver)2mg·kg~(-1)·d~(-1) 12wk后,心肌钙含量降低,组织学半定量检查和超微结构观察表明,心肌损害明显减轻,但对心肌血管损害影响较小,结果提示维拉帕米对慢性心肌损伤有保护作用,其机理可能与心肌钙含量降低有关。
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| 关 键 词： | 拉帕米 高血压 糖尿病 心肌病 钙 电子显微镜 |
Protective effect of verapamil on myocardium of experimental hypertensive-diabetic cardiomyopathy in rats |
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| WU LI-Qun,CHEN Da-Guang,CHEN Ri-Xin. Protective effect of verapamil on myocardium of experimental hypertensive-diabetic cardiomyopathy in rats[J]. Chinese Journal of Pharmacology and Toxicology, 1993, 7(1): 23-26 |
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| Authors: | WU LI-Qun CHEN Da-Guang CHEN Ri-Xin |
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| Abstract: | Myocardial ultrastructure,morphological characteristics and calcium concentration were studied in both renal hypertensive and streptozotocin induced diabetic(HD)rats treated with verapamil(2mg·kg-1·d-1 12 wk ig).Myocar dial calcium concentration was decreased from 75±s 17 to 44±s 24μg·g-1 Heart weight/body weight ratio was alternated.Perivascular fibrosis was significantly improved; however,no change in vascular sclerosis was observed.Nuclei and myofibrillae tended to the normal and matrix dense granules of mitochondria were reduced.It seems that verapamilhas the protective effect on the myocardium,which is likely related to the reduction of myocardial calcium concentration. |
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| Keywords: | Verapamil HypertensionDiabetes mellitus Myocardial diseases Calcium Electron microscopy |
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