改水降氟10年后儿童氟负荷及氟效应指标的调查

目的 为评价改水降氟对地方性氟中毒的防治效果。方法 检测分析了（未改水）病区组、改水病区组、非病区组８～１２岁儿童的尿氟和氟毒性效应指标。结果 尿氟均值病区组明显高于改水病区组（Ｐ〈０．０１）和非病区组（Ｐ〈０．０１）；尿羟脯氨酸（ＨＯＰ）排泄量均值病区级亦明显高于改水病区组（Ｐ〈０．０１）和非病区组（Ｐ〈０．０１）；改水病区组８～１２岁儿童氟斑牙患病率由１０年前的８２．４％降至６．４５％，明显低

A study of indices of children's body fluorine load and toxic effect after the years of defluoride of drinking water

Objective Assess the effects of defluoride of drinking water. Methods The urine fluorine and indices of fluoride toxic effect were determined for three groups of children which were 8-12 years old. The three groups were nondefluoride group,defluoride group and non-epidemic area group. Results The mean of urine fluorine of non-defluoride group was much higher than that of defluoride group (P <0. 01 ) and non-epi- demic area group(P < 0. 01 ).The mean of urine hydroxyproline (HOP) was much higher than that of defluoride group (P < 0. 01 ) and non-epidemic area group (P < 0. 01 ). After ten years of defluoride of drinking water,the rate of dental fluorosis dropped from 82.4% to 6. 45 %. The rate (6. 45 % ) was much lower than that of non- defluoride group(P < 0. 01 ). The dental fluorosis indices of non-defluoride group,defluoride group and non- epidemic area group were decrasing progressively,namely 0.73, 0.03, 0.026. In the non-defluoride group the mean of activity of urine creatine phosphokinase (CPK) was much higher than that in defluoride group (P<0. 01 ) and non-epidemic area group (P <0. 01 ). Between the defluoride group and non epidemic area group, the indices mentioned above have no significant difference (P > 0. 05 ). Conclusions After defluoride of drinking wafer,the body fluorid load came down and indices of fluoride toxic effect were improved,because of the decresing of expo- sure levels to fluorine.