神经节苷脂联合高压氧治疗重型颅脑损伤疗效观察

目的探讨神经节苷脂联合高压氧治疗重型颅脑损伤患者的临床疗效。方法 136例重型颅脑损伤患者分为常规治疗组33例、神经节苷脂组32例、高压氧组35例和神经节苷脂联合高压氧治疗组(联合治疗组)36例。常规治疗组患者给予常规治疗,神经节苷脂组、高压氧组、联合治疗组分别在常规治疗基础上加用神经节苷脂、高压氧及神经节苷脂联合高压氧治疗,观察患者治疗60 d后的意识状态、住院期间并发症及伤后180 d格拉斯哥预后评分情况。结果与常规治疗组比较,治疗过程中神经节苷脂组、高压氧组和联合治疗组的呼吸道感染发生率显著降低(P<0.008 3),神经节苷脂组、高压氧组和联合治疗组患者昏迷时间显著降低,差异有统计学意义(P<0.05),以联合治疗组最为显著;治疗60 d后联合治疗组患者未清醒比例显著低于常规治疗组、神经节苷脂组和高压氧组(P<0.008 3);伤后180 d联合治疗组预后良好率显著高于常规治疗组、神经节苷脂组和高压氧组(P<0.008 3)。结论神经节苷脂联合高压氧治疗重型颅脑损伤患者有确切疗效。

Therapeutic effect of ganglioside combined with hyperbaric oxygen treatment on severe traumatic brain injuries

Objective To investigate therapeutic effect of ganglioside combined with hyperbaric oxygen treatment on severe traumatic brain injury. Methods A total of 136 hospitalized patients with severe traumatic brain injury were divided into 4 groups：33 patients were treated with conventional therapy（ control group） ,32 patients were treated with ganglioside therapy （ganglioside group） ,35 patients were treated with hyperbaric oxygen therapy（ HBO group） and 36 patients were treated with ganglioside combined with hyperbaric oxygen therapy （ ganglioside ＋ HBO group）. States of consciousness, complications and short-term efficacy after treating for 60 days and Glasgow Outcome Scale of 180 days after injury in treated patients were observed. Results Compared with control group,the incidences of respiratory tract infection were significantly decreased in another three groups including ganglioside, HBO and ganglioside ＋ HBO group（P 〈 0.008 3 ）, and the durations of coma were also shorter significandy in these groups（P 〈0.05） ,especially in ganglioside ＋ HBO group. The recovery rate of consciousness after 60 days of treatment in ganglioside ＋ HBO group was higher significantly than those in control group, ganglioside group and HBO group（ P 〈 0. 008 3 ）. Also there was significantly higher of recent clinical efficacy 180 days after injury in ganglioside ＋ HBO group compared with control group, ganglioside group and HBO group （P 〈 0. 008 3 ）. Conclusion Ganglioside combined with hyperbaric oxygen treatment on severe traumatic brain injuries has exact effect .