苍附导痰汤治疗多囊卵巢综合征的临床研究

目的 研究苍附导痰汤对多囊卵巢综合征（PCOS）的临床疗效.方法 纳入2011年8月～2013年4月期间在我院妇科诊治的PCOS患者84例,随机分为观察组和对照组.对照组采用二甲双胍肠溶片治疗,500 mg/次,3次/d;观察组在对照组基础上给予苍附导痰汤,1剂/d,早晚温服,两组均治疗3个月.分别于治疗前后评估患者的生存质量,并检测性激素分泌水平和排卵情况.结果 治疗后,观察组的一般健康状况及精力优于对照组（P＜0.05）;而生理机能、生理职能、躯体疼痛、社会功能、情感职能及精神健康,两组均无显著性差异（P＞0.05）.对照组治疗前后比较,促黄体生成素（LH）、促卵泡激素（FSH）及睾丸素（T）差异均有统计学意义（P＜0.05）,而雌二醇（E2）和催乳素（PRL）差异无统计学意义（P＞0.05）;观察组治疗前后比较,LH、FSH、E2及T差异均有统计学意义（P＜0.05）,而PRL差异无统计学意义（P＞0.05）.对照组治疗前后排卵率比较差异无显著变化（P＞0.05）,而观察组治疗后的排卵率（90.48%）显著高于治疗前（64.29%）（P＜0.05）,也高于对照组治疗后（P＜0.05）.结论 苍附导痰汤联合二甲双胍肠溶片治疗PCOS疗效显著,优于单用二甲双胍肠溶片,值得临床推广使用.

Clinical research on treatment of polycystic ovarian syndrome with Cangfu Daotan decoction

Objective To study the clinical curative effects of Cangfu Daotan decoction on polycystic ovarian syndrome （ PCOS）. Methods Eighty four patients with PCOS who were treated between August 2011 and April 2013 were randomly divided into observation and control groups. The control group received the treatment with mefformin hydrochloride enteric-coated tablets, 500 mg/time and 3 times/d. The observation group received the treatment with Cangfu Daotan decoction a dose/d in the morning and evening based on the same therapy as the control group. The course of treatment was 3 months for both groups. Before and after treatment,the patients＇living quality was evaluated, and the sex hormone secretion levels and ovulation were detected. Results After the treatment, the overall health condition and vigor in the observation group were superior to those in the control group （P 〈 0.05）. There was no significant difference in the physiological functions, bodily pain, social function, emotional function, and mental health between the two groups （P 〉 0.05）. Before and after the treatment, there were significant differences in the luteinizing hormone （ LH）, follicle-stimulating hormone （FSH）, and testosterone （T） of the control group （P 〈0.05） ,while there was no significant difference in estradiol （E2） and prolactin （PRL） （ P 〉 0.05 ）. In the observation group before and after treatment, there were significant differences in LH, FSH, E2, and T （ P 〈 0.05 ）, but there was no significant difference in PRL （ P 〉 0.05 ）. In the control group, there was no significant difference in the ovulation rate before and after the treatment （ P 〉 0.05 ）, while that in the observation group after the treatment （90.48%） was significantly higher than that before the treatment （64.29%） （ P 〈 0.05） and also higher than that in the control group after the treatment （P 〈 0.05 ）. Conclusion Cangfu Daotan decoction combined with mefformin bydrochloride enteric- coated tablets has obvious curative effects on polycystic ovarian syndrome. The effect is superior to that of simple using metformin hydrochloride enteric-coated tablets.