大分割三维适形放疗联合吉西他滨治疗早期非小细胞肺癌

目的探讨大分割三维适形放疗(3DCRT)联合吉西他滨治疗早期非小细胞肺癌的疗效与不良反应。方法大剂量分割3DCRT治疗早期NSCLC28例,6～8Gy/次,隔日1次,3次/周,DT48～54Gy。并于放疗同期第1、8天给予吉西他滨600mg/m2。结果完全缓解率(CR)为39.3%,部分缓解率(PR)为60.7%,有效率(RR)为100%。1、2、3年总生存率为96.4%、78.6%和71.4%。结论大分割三维适形放疗联合吉西他滨治疗早期非小细胞肺癌有较好的疗效,可以改善生存,毒副反应可以耐受,是一种安全有效的治疗手段。

Three Dimensional Conformal Hypofractionated High Dose Radiotherapy Combined with Gemcitabine Concurrent Chemotherapy for Early-stage Non-Small-Cell Lung Cancer

Objective To evaluate the efficacy and toxicity of three dimensional conformal hypofractionated high dose radiotherapy combined with Gemcitabine concurrent chemotherapy for early-stage non-small-cell lung cancer. Methods 28 cases patients with early-stage non-small-cell lung cancer were treated by three dimensional conformal hypofractionated high dose radiotherapy at the total dose of 48 to 54 Gy , 6 to 8 Gy for each fraction, 3 f/w. And they were also given Gemcitabine concurrent chemotherapy： Gemcitabine 600mg/m2, d1, 8. Results The complete remission rate was 39.3% and partial remission rate was 60.7%.The overall response rate was 100%. The 1-, 2-, 3-year survival rates were 96.4%, 78.6% and 71.4%. Conclusion Three dimensional conformal hypofractionated high dose radiotherapy combined with Gemcitabine concurrent chemotherapy for early-stage non-small-cell lung cancer is effective, the survival rate can be improved, the side effects are tolerable. It is one of safe and effective treatment.