| M型磷脂酶A2受体及其抗体在特发性膜性肾病诊治中的作用 |
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| 引用本文： | 卢玥,李绍梅. M型磷脂酶A2受体及其抗体在特发性膜性肾病诊治中的作用[J]. 临床荟萃, 2018, 33(10): 839. DOI: 10.3969/j.issn.1004-583X.2018.10.003 |
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| 作者姓名： | 卢玥 李绍梅 |
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| 作者单位： | 河北医科大学第二医院 肾内科, 河北 石家庄 050000 |
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| 摘 要： | M型磷脂酶A2受体(M Type phospholipase A2 receptor, PLA2R)作为特发性膜性肾病(Idiopathic membranous nephropathy, IMN)的一种特异度自身抗体已被广泛证实，为IMN发病机制的研究开辟了新的思路。大量的临床资料表明，PLA2R及其抗体在膜性肾病的发病过程中起重要作用，且与疾病的活动性、严重程度及预后相关，甚至可以预测疾病复发，指导治疗时机的选择。本文对PLA2R及其抗体在IMN诊断和治疗过程中的应用价值进行综述。
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| 关 键 词： | 肾小球肾炎 膜性 M型磷脂酶A2受体 抗M型磷脂酶A2受体抗体 |
Role of M-type phospholipase A2 receptor and its antibody in diagnosis and treatment of idiopathic membranous nephropathy |
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| Lu Yue,Li Shaomei. Role of M-type phospholipase A2 receptor and its antibody in diagnosis and treatment of idiopathic membranous nephropathy[J]. Clinical Focus, 2018, 33(10): 839. DOI: 10.3969/j.issn.1004-583X.2018.10.003 |
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| Authors: | Lu Yue Li Shaomei |
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| Affiliation: | Department of Nephrology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China |
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| Abstract: | M-type phospholipase A2 receptor (PLA2R) has been widely confirmed as a specific auto antibody for Idiopathic membranous nephropathy (IMN), which has opened up a new train of thought the pathogenesis of IMN . A large number of clinical data indicate that PLA2R and its antibody play an important role in the pathogenesis of IMN, and are related to the activity, severity and prognosis of the disease. It can even predict disease recurrence and guide the timing of treatment. This article reviews the application value of PLA2R and its antibody in the diagnosis and treatment of IMN. |
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| Keywords: | glomerulonephritis, ,membranous；M type phospholipase A2 receptor anti PLA2R, |
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