银杏二萜内酯葡胺联合阿替普酶治疗急性缺血性脑卒中临床研究

目的:观察银杏二萜内酯葡胺联合阿替普酶对急性缺血性脑卒中(AIS)患者神经功能、Sestrin2蛋白、同型半胱氨酸(Hcy)、血浆黏度、红细胞比容及血小板黏附率的影响。方法:选取200例AIS患者,按随机数字表法分为对照组与观察组,每组100例。对照组给予阿替普酶治疗,观察组在对照组基础上加用银杏二萜内酯葡胺治疗。比较2组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分,Sestrin2蛋白、Hcy水平及血液流变学指标。结果:治疗后,2组NIHSS评分均较治疗前降低(P<0.05),观察组NIHSS评分低于对照组(P<0.05)。治疗后,2组Sestrin2蛋白、Hcy水平及血浆黏度、红细胞比容、血小板黏附率均较治疗前降低(P<0.05),观察组Sestrin2蛋白、Hcy水平及血浆黏度、红细胞比容、血小板黏附率均低于对照组(P<0.05)。结论:银杏二萜内酯葡胺联合阿替普酶可改善AIS患者的神经功能、血液流变学指标,降低Sestrin2蛋白、Hcy水平。

Clinical Study on Ginkgo Diterpene Lactone Glucamine Combined with Alteplase forAcute Ischemic Stroke

Objective:To observe the effect of ginkgo diterpene lactone glucamine combined with alteplase on neurological function,sestrin2,homocysteine(Hcy),plasma viscosity,hematocrit and platelet adhesion rates in patients with acute ischemic stroke(AIS).Methods:A total of 200 cases of AIS patients were divided into the control group and the observation group according to the random number table method,with 100 cases in each group.The control group was treated with Alteplase,and the observation group was treated with Ginkgo Diterpene Lactone Glucamine additionally,Before and after treatment,the scores of National Institutes of Health Stroke Scale(NIHSS),levels of sestrin2 and Hcy,and hemorheology indexes in the two groups were compared.Results:After treatment,the NIHSS scores in the two groups were decreased when compared with those before treatment(P<0.05),and the NIHSS score in the observation group was lower than that in the control group(P<0.05).After treatment,levels of sestrin2 and Hcy,plasma viscosity,hematocrit and platelet adhesion rates in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of sestrin2 and Hcy,plasma viscosity,hematocrit and platelet adhesion rate in the observation group were lower than those in the control group(P<0.05).Conclusion:Ginkgo diterpene lactone glucamine combined with alteplase for AIS patients can improve their neurological function and hemorheological indexes,and reduce the levels of sestrin2 protein and Hcy.