加减补阳还五汤联合地奥司明治疗下肢慢性静脉功能不全临床研究

目的:观察加减补阳还五汤联合地奥司明治疗下肢慢性静脉功能不全的临床效果.方法:选取52例下肢慢性静脉功能不全患者,采用随机数字表法分为治疗组与对照组各26例.对照组给予地奥司明治疗,治疗组在对照组的基础上给予加减补阳还五汤治疗.治疗8周后,观察2组临床疗效、症状评分及血清炎症因子[白细胞介素-6 (IL-6)、肿瘤坏死...

Clinical Study on Modified Buyang Huanwu Tang Combined with Diosmin for ChronicVenous Insufficiency of Lower Limbs

Objective:To observe the clinical effect of modified Buyang Huanwu tang combined with diosmin for chronic venous insufficiency of lower limbs.Methods:A total of 52 cases of patients with chronic venous insufficiency of lower limbs were divided into the treatment group and the control group according to the random number table method,with 26 cases in each group.The control group was treated with diosmin,and the treatment group was additionally treated with modified Buyang Huanwu tang based on the treatment of the control group.After eight-week treatment,the clinical effects and symptoms scores as well as changes in levels of inflammatory factors including interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in serum in the two groups were observed.Results:The total effective rate was 92.31%in the treatment group and 69.23%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of scores of pain,a sense of heaviness,swelling and reflux time of deep vein blood flow between the two groups(P>0.05);after treatment,the above symptom scores in the two groups were decreased when compared with those before treatment(P<0.05),and the scores in the treatment group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of inflammatory factors including IL-6 and TNF-αin serum between the two groups(P>0.05);after treatment,the levels of IL-6 and TNF-αin the two groups were decreased when compared with those before treatment(P<0.05),and the levels of IL-6 and TNF-αin the treatment group were lower than those in the control group(P<0.05).Conclusion:Modified Buyang Huanwu tang combined with diosmin has a significant curative effect in treating chronic venous insufficiency of lower limbs,which can effectively relieve clinical symptoms and inflammatory responses.