| 复方自微乳中姜黄素和胡椒碱的体外释放研究 |
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| 引用本文： | 任金妹,李曼,王晶,顾申勇. 复方自微乳中姜黄素和胡椒碱的体外释放研究[J]. 药学实践杂志, 2022, 40(1): 66-69,75 |
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| 作者姓名： | 任金妹 李曼 王晶 顾申勇 |
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| 作者单位： | 复旦大学附属中山医院青浦分院，上海 201700 |
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| 基金项目： | 上海市卫生和计划生育委员会科研课题计划资助（20174y0064）；上海市青浦区科技发展基金项目（QKY2019-18）；青浦区卫生健康系统第四轮人才培养（WY2019-17） |
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| 摘 要： | 目的 考察复方自微乳中姜黄素和胡椒碱的体外释放行为.方法 采用动态透析法,分别以pH值为4.8、7.5的磷酸盐缓冲液并加入0.75％吐温-80作为漏槽条件,考察姜黄素和胡椒碱的体外释放特性.结果 姜黄素在pH 4.8和pH 7.5释放介质中108 h累积释放百分率分别为94.85％和84.38％.胡椒碱在上述介质中36...
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| 关 键 词： | 姜黄素 胡椒碱 复方自微乳 体外释放 缓释 |
| 收稿时间： | 2020-09-27 |
| 修稿时间： | 2021-03-23 |
In vitro release study on self-microemulsion of curcumin and piperine |
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| REN Jinmei,LI Man,WANG Jing,GU Shenyong. In vitro release study on self-microemulsion of curcumin and piperine[J]. The Journal of Pharmaceutical Practice, 2022, 40(1): 66-69,75 |
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| Authors: | REN Jinmei LI Man WANG Jing GU Shenyong |
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| Affiliation: | Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, China |
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| Abstract: | Objective To study the release profile of curcumin and piperine from the compound self-microemulsion.Methods The release of curcumin and piperine in vitro was investigated by dynamic dialysis under the condition of phosphate buffer of pH 4.8 and 7.5 with 0.75% Tween-80.Results The cumulative release rates of curcumin in pH 4.8 and pH 7.5 were 94.85% and 84.38% in 108 h, respectively. The cumulative release rates of piperine were 92.85% and 90.05% in 36 h, separately.Conclusion Curcumin and piperine in self-microemulsion have sustained release properties and released more in the acidic environment similar to the environment in tumors. |
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| Keywords: | curcumin piperine self-microemulsifying drug delivery in vitro release sustained release |
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