丹参化学成分、药理作用及其质量标志物(Q-Marker)的预测分析

丹参因含丹参酮类、丹酚酸类、挥发油类、多糖类和含氮化合物等化学成分,具有抗凝血、抗炎、抗氧化、抗纤维化、抗肿瘤、保护脏器的作用,并在中药复方配伍和相关制剂中成为常用中药.在丹参化学成分和药理活性的基础上,从成分特有性、有效性、可测性、可入血成分及网络药理学预测5个不同角度对丹参质量标志物(quality marker,...

Chemical components and pharmacological action for Salviae Miltiorrhizae Radix et Rhizoma and predictive analysis on quality markers

Danshen (Salviae Miltiorrhizae Radix et Rhizoma) has the functions of anti-coagulation, anti-inflammation, anti-oxidation, anti-fibrosis, anti-tumor, liver protection because of its chemical components such as tanshinones, salvianolic acids, volatile oils, polysaccharides and nitrogen-containing compounds, it also has traditional Chinese medicine compound become a common traditional Chinese medicine in compatibility and related preparations. Based on the chemical components and pharmacological activities of Salviae Miltiorrhizae Radix et Rhizoma, the quality markers (Q-Marker) of Salviae Miltiorrhizae Radix et Rhizoma from five different perspectives:Component specificity, effectiveness, measurability, blood components and network pharmacology prediction are analyzed and predicted in this article. It is recommended to combine six phenolic acids (tanshinone, protocatechualdehyde, rosmarinic acid, shikonic acid, salvianolic acid A and salvianolic acid B) and four tanshinones (dihydrotanshinone I, cryptotanshinone, tanshinone I and tanshinone II_A) as a reference for the selection of Q-Marker of Salviae Miltiorrhizae Radix et Rhizoma, in order to establish a more scientific quality evaluation system for solving the quality problems of Salviae Miltiorrhizae Radix et Rhizoma and provide reference for formulating high-level quality standards.