健脾补肾活血方对脑梗死患者神经功能缺损和T细胞亚群的影响

目的:评价健脾补肾活血方治疗脑梗死的临床疗效及其对细胞免疫功能的影响.方法:采用随机数字表法将脑梗死患者随机分为治疗组和对照组各30例,对照组采用西药常规治疗,治疗组在西药常规治疗的基础上加服具有扶正固本作用的中药健脾补肾活血方,14 d为1个疗程,共观察2个疗程.分别评定两组患者治疗前及治疗后7,14,28 d卒中量表(NIHSS)评分,并用流式细胞仪检测治疗前后外周血T淋巴细胞亚群变化.结果:治疗组显效率76.67％,总有效率93.33％.对照组显效率40.0％,总有效率73.33％.治疗组疗效明显高于对照组(P＜0.01,P＜0.05).两组患者治疗后NIHSS评分较治疗前均明显下降(P＜0.01).治疗后治疗组NIHSS评分较对照组下降更明显(P＜0.01).两组患者治疗后CD3+,CD4+,CD4+/CD8+较治疗前均明显增加(P＜0.01),CD8+明显下降(P＜0.01).治疗后治疗组CD3+,CD4+,CD4+/CD8+较对照组增加更明显(P＜0.01),CD8+下降也较对照组更明显(P＜0.01).结论:具有扶正固本作用的中药健脾补肾活血方能够改善脑梗死患者临床症状和体征,临床疗效明显,并且可以明显改善患者的细胞免疫功能.

Influence of Jianpi Bushen Huoxue Fang Treated on Nerve Functional Lack and T Cell Subsets of Cerebral Infarct Patients

Objective:To evaluate the clinical effect of the Jianpi Bushen Huoxue Fang treated on cerebral infarct and its influence on cell immune function. Method: Sixty patients suffered from cerebral infarct were divided into two average groups including the treatment group and the control group at random, the two groups were both treated with routine western medicine, besides this, the treatment group was dosed the Jianpi Bushen Huoxue Fang additionally which could strengthen body resistance, 14 days is a period of treatment, we observed two periods. Assessing the two groups respectively before and after treatment of 7, 14,28 days with the national institutes of health storke scale(NIHSS) score,at the same time, the change of the peripheral blood T cell subsets was measured by flow cytometry in both groups before and after treatment. Result: The significance of the treatment group was 76.76% and the total effective rate was 93.33%, while the number was 40.0% and 73.33% in the control group. The curative effect of the treatment group is higher obviously than that of the control group (P<0.01,P<0.05). The NIHSS score after treatment declined obviously in both groups(P<0.01),and it is much more significant for the treatment group(P<0.01). The number of CD3⁺,CD4⁺,CD4⁺/CD8⁺ in both groups increased obviously(P<0.01) while the number of CD8⁺ decreased significantly(P<0.01) after treatment, and the number of CD3⁺,CD4⁺,CD4⁺/CD8⁺ in treatment group increased much more than control group(P<0.01), the number of CD8⁺ also decreased much more than control group(P<0.01). Conclusion: The Jianpi Bushen Huoxue Fang, which has the effect of strengthening body resistance, could improve the clinical symptom and sign of cerebral infarct patients and enhance the function of cell immune, the clinic curative effect is significant.