降脂汤对高脂血症患者血管内皮功能及hsCRP的影响

目的:探讨降脂汤对高脂血症患者血脂水平、血管内皮功能及hsCRP的影响.方法:60例原发性高脂血症患者随机分为治疗组和对照组各30例,治疗组采用降脂汤方(配方颗粒),1剂/d,口服,对照组采用辛伐他汀,20 mg,1次/d,口服.疗程8周.观察血脂水平,采用放射免疫法测定血内皮素(ET),采用硝酸还原法测定血清一氧化氮(NO),采用双抗体夹心酶联免疫吸附测定法超敏C反应蛋白(hs-CRP),并进行血管内皮依赖性血流介导的舒张功能(FMD)的检测.结果:治疗后两组TC,TG,LDL-C明显降低,HDL-C明显升高,治疗后组间差异不明显；两组ET-1和hs-CRP明显降低,NO和FMD明显升高；治疗组ET-1和FMD与对照组比较差异显著.结论:降脂汤能改善患者高脂状态,明显改善血管内皮功能,降低血浆hs-CRP水平,这可能是其降脂作用机制.

Effect of Jiangzhi Decoction on Vascular Endothelial Function and HsCRP of Patients with Hyperlipidemia

Objective: To investigate the effect of Jiangzhi decoction on lipid levels, vascular endothelial function and hsCRP of Patients with hyperlipidemia. Method: Sixty patients with primary hyperlipidemia were randomly divided into treatment group (n=30) and control group (n=30).The treatment group was treated with lipid-lowering soup side (recipe granules),once daily. The control group was treated with simvastatin, 20 mg once daily, all for 8 weeks. Lipid levels were measured; blood endothelin (ET) was determined by radioimmunoassay; serum nitric oxide (NO) was observed by nitrate reduction method; high-sensitivity C-reactive protein (hs-CRP) was monitored by ELISA; and endothelium-dependent flow-mediated diastolic function (FMD) was also detected. Result: After treatment, in both groups, TC, TG, LDL-C were decreased significantly, HDL-C was increased significantly. No significant difference appeared between the two groups after treatment. In the two groups, ET-1 and hs-CRP were significantly lowered, NO and FMD was significantly increased. ET-1 and FMD of the treatment group showed significant difference compared with those in the control group (P<0.05). Conclusion: Jiangzhi decoction can improve the status of patients with hyperlipidemia. It is likely related to improvement in endothelial function and decrease in plasma hs-CRP level.