| 解毒抗白颗粒剂的含量测定及初步稳定性研究 |
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| 引用本文： | 李耀华,蔡乐,钟鸣,卢森华,陈勇,辛华. 解毒抗白颗粒剂的含量测定及初步稳定性研究[J]. 中国实验方剂学杂志, 2013, 19(3): 97-100 |
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| 作者姓名： | 李耀华 蔡乐 钟鸣 卢森华 陈勇 辛华 |
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| 作者单位： | 1. 广西中医药大学,南宁 53000
2. 广西民族医药研究院,南宁,530001 |
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| 基金项目： | 广西科技攻关课题(桂科攻0718002-2-12) |
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| 摘 要： | 目的:建立解毒抗白颗粒的含量测定方法,并考察制剂的稳定性.方法:采用HPLC法对制剂中半枝莲有效成分野黄芩苷含量进行测定,色谱柱为C18柱(4.6 mm×250 mm,5μm),流动相为甲醇-0.1％磷酸溶液(34∶66),检测波长为335 nm;同时对三批样品进行了初步稳定性试验考察.结果:野黄芩苷进样量在0.260 ～ 2.60μg之间与峰面积值呈线性关系,r=0.999 9,平均回收率为100.7％,RSD2.6％(n=6);初步稳定性试验表明,制剂在性状、粒度、水分、装量差异、溶解度和含量测定等方面均符合规定.结论:所建立的含量测定方法可行,制剂质量可控,稳定性良好.
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| 关 键 词： | 解毒抗白颗粒 野黄芩苷 初步稳定性 |
| 收稿时间： | 2012-07-27 |
Studies on the Content Determination and Preliminary Stability of Formulated Granules of Detoxification and Anti-Leukaemia |
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| LI Yao-hu,CAI Le,ZHONG Ming,LU Sen-hu,CHEN Yong and XIN Hua. Studies on the Content Determination and Preliminary Stability of Formulated Granules of Detoxification and Anti-Leukaemia[J]. China Journal of Experimental Traditional Medical Formulae, 2013, 19(3): 97-100 |
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| Authors: | LI Yao-hu CAI Le ZHONG Ming LU Sen-hu CHEN Yong XIN Hua |
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| Affiliation: | Faculty of Pharmacy, Guangxi University of Traditional Chinese Medicine, Nanning 530001, China;Faculty of Pharmacy, Guangxi University of Traditional Chinese Medicine, Nanning 530001, China;Guangxi National Institute of Medical Research, Nanning 530001, China;Faculty of Pharmacy, Guangxi University of Traditional Chinese Medicine, Nanning 530001, China;Faculty of Pharmacy, Guangxi University of Traditional Chinese Medicine, Nanning 530001, China;Faculty of Pharmacy, Guangxi University of Traditional Chinese Medicine, Nanning 530001, China |
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| Abstract: | |
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| Keywords: | formulated granules of detoxification and anti-leukaemia scutellarin preliminary stability |
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