半夏泻心汤抗抑郁作用实验研究

目的:探讨中药经方半夏泻心汤(BXT)抗抑郁作用.方法:补给药途径、天数及与检测的时间关系120只成年雄性昆明种小鼠随机分为空白组(Control；n=24),阳性药氟西汀组(FLU,10 mg·kg-1,ig,n=24),BXT低、中、高剂量组(50,100,200 mg· kg-1；n=24),分别进行旷场实验(open field test,OFT;n =8)、悬尾实验(tail suspension test,TST;n =8)和强迫游泳实验(forced swimming test,FST；n=8)；OFT实验参数包括水平运动得分、垂直运动得分和总得分,TST和FST实验参数是不动状态持续时间.结果:OFT结果提示,与Control比较,FLU和BXT低、中、高剂量对OFT水平运动得分、垂直运动得分及总得分影响差异均无统计学意义；TST结果提示,与Control比较,FLU和BXT低、中、高剂量可明显缩短TST不动状态持续时间(P＜0.01,P＜0.05,P＜0.01,P＜0.01)；FST结果提示,与Control比较,FLU和BXT低、中、高剂量可明显缩短FST不动状态持续时间(P＜0.01,P＜0.05,P＜0.01,P＜0.01).结论:半夏泻心汤具有明显抗抑郁作用,但其具体作用机制尚未明确.

Antidepressant-like Effect of Banxia Xiexin Tang

Objective: To explore the antidepressant-like effect of a traditional Chinese medicine, Banxia Xiexin Tang(BXT). Method: One hundred and twenty mice were divided into five groups(n=24), such as control group, fluoxetine(FLU) group, BXT(50, 100, 200 mg·kg^-1) groups. The behavior of each group in open field test(OFT,n=8), tail suspension test(TST,n=8) and forced swimmig test(FST,n=8) was recorded. The following parameters were evaluated:the number of horizontal squares, number of rearings and total score for OFT, the latency to the first bout of immobility and duration of immobile time during the last 4 min of the 6-min trial for TST and FST. Result: FLU and BXT decreased the duration of immobile time during the last 4 min of the 6-min trial in both TST and FST, and the latency to the first bout of immobility in FST, however, had no effect on OFT activcity, such as number of horizontal squares and number of rearings. Conclusion: BXT has a good antidepressant-like effect on mice depression model.