龙胆泻肝汤加减治疗带状疱疹伴中、重度抑郁情绪

目的:探讨龙胆泻肝汤加减治疗带状疱疹(HZ)患者伴中、重度抑郁情绪的临床疗效.方法:74例存在中、重度抑郁情绪的带状疱疹患者随机分为观察组与对照组各37例,对照组给予口服泛昔洛韦0.25 g,bid,抗病毒治疗7d,同时联合氟哌噻吨2片,bid治疗14 d,观察组在对照组治疗基础上加服龙胆泻肝汤,并随证加减,疗程均为2周.观察HZ的疗效,并对治疗前后抑郁情绪、疼痛程度及睡眠质量进行评定.结果:两组总有效率分别为94.5％,64.9％；观察组明显高于对照组(P＜0.01).治疗后观察组抑郁情绪、疼痛及睡眠评分的改善均优于对照组(P＜0.01).两组用药过程中均无明显不良反应.结论:中西医结合治疗带状疱疹伴中、重度抑郁情绪疗效肯定.

Treatment of Herpes Zoster with Middle and Severe Depressive Emotion by Longdan Xiegan Decoction

Objective: To investigate the clinical efficacy Longdan Xiegan decoction (LXD) for treating herpes zoster (HZ) in patients with middle and severe depressive emotion. Method: Seventy-four herpes zoster patients with middle and severe depressive emotion were randomly divided into observation group and the control group (n=37 each). The control group was given oral famciclovir (0.25 g,bid) antiviral treatment for 7 d, combined with flupentixol 2 tables bid for 14 d, the observation group was given additional treatment on the basis of the control group with LXD modified according to the different syndromes. The treatment lasted 2 weeks. HZ efficacy, and the treatment of depression, pain and sleep before and after treatment were observed and assessed. Result: The two groups showed efficiency of 94.5% and 64.9% accordingly; the observation group was significantly higher than that in the control group (P<0.01). The depression, pain and sleep scores of the observation group were improved and better than those in the control group (P<0.01). No significant adverse reactions in the two groups in the medication process. Conclusion: Treatment of integrated traditional Chinese and western medicine for herpes zoster with middle and severe depressive emotion is effective.