柏子滋阴润肠汤治疗慢性功能性便秘116例

目的:探讨柏子滋阴润肠汤治疗慢性功能性便秘(CFC)的临床疗效及对结肠传输功能的影响。方法:116例CFC患者随机分为治疗组59例和对照组57例。治疗组采用柏子滋阴润肠汤加减,1剂/d,对照组采用麻仁润肠软胶囊,8粒/次,2次/d。疗程均为4周。观察排便困难、Bristol评分、排便时间、排便次数及腹胀等症状,并进行结肠传输试验。结果:治疗后治疗组排便困难等症状积分均明显低于对照组(P<0.01);治疗后及治疗后4周治疗组全结肠通过时间均短于对照组(P<0.01);治疗后治疗组总有效率为93.22%,优于对照组的77.19%(P<0.05)。治疗后两组复发率无显著差异。结论:柏子滋阴润肠汤治疗CFC有显著的临床疗效,安全性好,有临床推广应用价值。

Clinical Research on Bozi Ziyin Runchang Decoction for Treatment of 116 Cases of Chronic Functional Constipation

Objective: To study the clinical curative effect of Bozi Ziyin Runchang decoction (BZRD) for treatment chronic functional constipation (CFC) and the influence on the colon transmission function. Method: One hundred and sixteen cases of CFC were randomly divided into treatment group and control group,59 cases and 57 cases respectively.The treatment group was given BZRD, 1 agent/daily, the control group was given Maren Runchang soft capsule, 8 capsules, bid. Period of treatment was 4 weeks. Symptom of defecation difficult, Bristol score, defecation time, defecation frequency and abdominal distension, and begin colon transmission test were observed. Result: After treatment, the treatment group's symptom defecation difficult was significantly lower than that in control group (P<0.01); after the treatment and 4 weeks after treatment,whole colon transmission time in the treatment group was less than that in control group (P<0.01); after treatment, the treatment group total effectiveness was 93.22%, which is higher than that of 77.19% in control group (P<0.05). After treatment, the two groups of the recurrence rate difference was not obvious. Conclusion: BZRD for treatment of CFC has significant clinical curative effect, good safety, promising clinical application.