小蓟流动性饮片的制备及其与传统饮片的比较

目的:优选小蓟新型流动性饮片的制备工艺,并与传统小蓟饮片进行比较。方法:以蒙花苷质量分数为指标,选取粉碎度、加水量、滚丸转速为考察因素,采用正交试验优选流动性饮片的制备工艺;利用TLC,HPLC,红外等对小蓟传统饮片和流动性饮片进行比较。结果:优选的制备工艺为粉碎度80目,加1.8倍量水,滚圆转速300 r.min-1,制备的流动性饮片平均粒径(1.94±0.20)mm,圆整度9.09～27.7,堆密度0.394 3 g.cm-3,真密度0.655 7 g.cm-3,平均硬度6.2 N,平均脆碎度0.30%。二者TLC图谱相同,传统饮片和流动性饮片中蒙花苷分别为0.64%,0.72%。二者煎出曲线较为接近,小蓟流动性饮片和传统饮片煎液的红外图谱基本一致。结论:小蓟新型流动性饮片和传统型饮片在药学上具有对等性,可替代使用。

Preparation of Flow Yinpian of Cirsium setosum and Comparison with Traditional Pieces

Objective: To optimize preparation technology for Flow Yinpian of Cirsium setosum,and compare with traditional Yinpian of C. setosum. Method: With the mass fraction of linarin as index,orthogonal method was used to investigate influence of grinding degree,the amount of water,roll pill speed on preparation technology;TLC,HPLC,SD-IR were used to compare traditional Yinpian with Flow Yinpian of C. setosum. Result: Optimized preparation technology was as following:grinding degree 80 mesh,the amount of water 1.8 times,roll pill speed 300 r· min^-1,mean particle size of prepared Flow Yinpian of (1.94±0.20) mm, roundness of 9.09-27.7,bulk density 0.394 3 g· cm^-3,true density 0.655 7 g·cm^-3,mean hardness 6.2 N,mean friability 0.30%.Their TLC were similar,the content of linarin was 0.64% in traditional Yinpian,while it was 0.72% in Flow Yinpian.Decoction curve of them was close,IR spectroscopy of their decoction was nearly the same. Conclusion: Traditional Yinpian and Flow Yinpian of C. setosum was reciprocity in pharmacy,they could substitute for each other.