活血促愈胶囊对外伤血瘀证大鼠模型的影响

目的:探讨活血促愈胶囊对急性软组织损伤引起的外伤血瘀证大鼠模型的影响.方法:用自由落体组织损伤法建立外伤血瘀证大鼠模型,造模后,将动物随机分为模型对照组、三七伤药胶囊对照组、活血促愈胶囊低、中、高剂量组(2.75,8.25,16.50 g·kg-1),每组动物10只,每天测小腿周长及损伤部位的机械刺激痛阈值；各治疗组分别ig相应的药物,共5d.然后肉眼观察局部组织损伤程度,进行病理组织学检查,并观察活血促愈胶囊对血液流变学的影响,另设正常对照组.结果:活血促愈胶囊能明显抑制外伤血瘀大鼠受伤部位的软组织肿胀(P＜0.01),减轻机械刺激引起的受伤部位的软组织疼痛(P＜0.01),并能降低外伤血瘀大鼠全血黏度(P＜0.01),提高红细胞聚集指数(P＜0.05),病理检查结果亦表明对外伤血瘀大鼠受伤部位的软组织损伤有明显的修复作用(P＜0.01).结论:活血促愈胶囊对急性软组织损伤引起的外伤血瘀证具有一定的治疗作用.

Effects of Huoxue Cuyu Capsule on Rats with Acute Blood Stasis

Objective: To study the effects of Huoxue Cuyu capsule on acute soft tissue injury in rats with acute blood stasis. Method: The rat model with acute blood stasis was estalished by freely falling mass damsges models. After modeling, rats were at random divided into model control group,Sanqi capsule control groups, low dose group, middle dose groups and high dose group(2.75,8.25,16.50 g·kg^-1)of Huoxue Cuyu capsule,10 rats each group. calf circumference and the threshold value of mechanical stimulus in injuries was tested every day. Rats were treated with oral medication daily for 5 days,the visual observation of local tissue damage, histological examination,determination of blood viscosity was made. A normal control group was set up in addion. Result: Huoxue Cuyu capsule had an apparent effect on acuting soft tissue injury in rats with acuting blood stasis, easing the suffer in soft tissue injury from the mechanical stimulus, reducing the blood viscosity, and increasing the erythrocyte aggregation index, also it had an obvious utility in reparing the soft tissue injury. Conclusion: Huoxue Cuyu capsule is benefit for acuting soft tissue injury from blood stasis.