养血清脑颗粒中有效成分的肠外翻吸收研究

目的:研究养血清脑颗粒中2种主要有效成分芍药苷和阿魏酸在大鼠不同肠段的肠外翻模型中的吸收动力学特征。方法:采用大鼠肠外翻模型,高效液相色谱法测定含量,计算养血清脑颗粒中芍药苷和阿魏酸的吸收参数,分析其在不同部位的吸收特征。结果:养血清脑颗粒中芍药苷和阿魏酸在各肠段均为线性吸收,相关系数的平方(R2)均达到0.9以上,符合零级吸收速率。肠道不同部位的吸收实验表明,其最佳吸收部位为回肠。结论:养血清脑颗粒中芍药苷和阿魏酸在肠道不同部位吸收均符合零级吸收速率。

Absorption of Active Ingredients in Yangxue Qingnao Granule in Rat Everted Gut Scas

Objective: The everted gut scas in vitro was used to investigate intestinal absorption kinetics characteristics of paeoniflorin and ferulic acid from Yangxue Qingnao granule at different intestinal section. Method: In vitro everted gut model was applied. The absorption concentration of paeoniflorin and ferulic acid, was detected by HPLC, and the absorption parameter was calculated for describing the absorption characters. Result: The absorption of paeoniflorin and ferulic acid was linearity in different intestine,and the square of coefficient correlation exceed 0.9,which consistent with zero order rate process. The absorption of paeoniflorin and ferulic acid in ileum was quick. Conclusion: The absorption of paeoniflorin and ferulic acid in Yangxue Qingnao granule conforms to the zero order rate process at different sections of intestine.