绝经后的妇女骨丢失与性激素和骨钙素测定的临床研究

为了解绝经妇女血清Ca、P、AKP(碱性磷酸酶)、性激素和骨钙素的水平，探讨绝经妇女的骨合成和骨丢失的发病机理，本文对177例绝经妇女，按不同绝经年限分为5组，用放免法测定血清总雌二醇(E2)、睾酮(T)、骨钙素(BGP)；用免放法测定血清促黄体生成素(LH)、促卵泡激素(FSH)、泌乳素(PRL)；用生化分析法测定Ca、P、AKP。结果显示：绝经妇女E2、T降低，E2最为明显，LH、FSH升高，PRL略降低。结论：绝经妇女雌激素缺乏和卵巢功能衰退是骨丢失的重要原因。

Clinical Study on Osteopenia,Serum Sexual Hormones and BGP Level in the Menopausal Women

In order to clarify the mechanism of osteogenesis and osteopenia of the menopausal women,serum Ca 2+ ],P 3+ ],AKP,sexual hormones and BGP level were investigated.The blood samples were taken from 177 female individuals who were divided into 5 groups based on different ages of menopause.Serum estradiol,testosterone and BGP were meassured by RIA.Serum LH,FSH and PRL were determined by IRMA.Serum Ca 2+ ],P 3+ ],AKP were determined by biochemistry analytical methods.Results showed that serum E 2 and T levels in the menopausal women were lower than those in the normal,E 2 decreased significantly.Meanwhile,serum PRL level was only a little lower,but the menopausal female had the higher levels of LH and FSH.Conolusion: the most important cause of osteopenia for the menopausal women is the deficiency of estrogen and degeneration of ovarian function.