| nm23-H1基因在乳腺癌组织中的表达及其临床意义 |
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| 引用本文： | 逄小红,李效良,刘京升,宗传龙.nm23-H1基因在乳腺癌组织中的表达及其临床意义[J].泰山医学院学报,2004,25(5):410-411. |
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| 作者姓名： | 逄小红 李效良 刘京升 宗传龙 |
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| 作者单位： | 泰山医学院,山东,泰安,271000 |
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| 摘 要： | 目的研究乳腺癌组织中nm23-H1基因的表达及其临床意义。方法采用免疫组化S—P法检测nm23-H1基因在88例乳腺癌组织中的表达。结果88例乳腺癌组织中46例nm23-H1表达阳性，阳性率为52.3％，nm23-H1的表达与乳腺癌的组织学分级、临床分期以及淋巴结转移呈负相关。nm23-H1阴性表达患者淋巴结转移率高。结论乳腺癌组织中nm23-H1的表达与乳腺癌的转移有相关性，可作为预测乳腺癌侵袭转移行为的生物学指标。
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| 关 键 词： | 乳腺癌组织 表达 nm23-H1基因 临床意义 淋巴结转移 S—P法 组织学分级 负相关 生物学指标 行为 |
| 文章编号： | 1004-7115(2004)05-0410-02 |
| 修稿时间： | 2004年6月12日 |
Expression of nm23-H1 and its clinical impact in breast cancer |
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| PANG Xiao-hong,Li Xiao-liang,Liu Jing-sheng,Zong Chuan-long.Expression of nm23-H1 and its clinical impact in breast cancer[J].Journal of Taishan Medical College,2004,25(5):410-411. |
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| Authors: | PANG Xiao-hong Li Xiao-liang Liu Jing-sheng Zong Chuan-long |
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| Abstract: | Objective: To study the expression of nm23-H1 and its clinical impact in breast cancer. Methods: The expression of nm23-H1 antigen was detected with immunohistochemical method in 88 breast cancers. Results: The positive immunohistochemical staining for nm23-H1 antigen was observed in 46 of all patients, the positive ratio being 52.3%. The expression of nm23-H1 antigen was significantly associated with differentiation, clinical stage and lymph node metastasis in breast cancer. Conclusion: The expression of nm23-H1 antigen was associated with tumor metastasis and may be a pathological biology index to judge the metastasis of breast cancer. |
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| Keywords: | breast cancer nm23-H1 metastasis |
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