肺癌与胚胎肺组织性激素受体的表达及意义

探讨原发性肺癌和肺组织雌激素受体（ＥＲ）和孕激素受体（ＰＲ）的表达和意义。方法应用荧光组织化学法测定两种受体。结果肺癌ＥＲ阳性２３．８％（１０／４２），ＰＲ阳性２８．６（１２／４２）；胚胎肺ＥＲ、ＰＲ阳性率男胚均为３０％，女胚均为４０％；非肿瘤肺ＥＲ、ＰＲ全部阴性。肺癌组中，ＥＲ、ＰＲ阳性肿瘤以鳞癌为主；组织分化好其ＥＲ受体有阳性表达倾向，低分化癌及小细胞癌表达倾向阴性。结论与乳癌相似，肺癌中ＰＲ是雌激素诱导合成的蛋白质和反映功能性ＥＲ的标记物；ＥＲ、ＰＲ表达在一定程度上反映癌的分化程度，分化好的癌ＥＲ和ＰＲ阳性率高；ＥＲ和ＰＲ阳性的肺癌为激素依赖性肿瘤，与雌激素靶器官的恶性肿瘤一致，可试用内分泌治疗

A Study on the Assay of Sex Hormone Receptor in Lung Carcinoma and Lung of Fetusess

Objective The distribution of estrogen receptor (ER) and progesterone receptor (PR) was studied.in the tumor tissue of 42 cases of lung cancers,5 cases of no-lung cancers and 30 cases of fetal lung tissue. Methods This study used fluorescent estradiol histochemical technique. Results The positive rates of ER and PR in lung cancers were 23.8% (10/42) and 28.6% (12/42),in fetusess lung were 40% (12/30),whereas they were negative in 5 cases of non-lung cancer.According to histologic types,eight squamous cell carcinomas,two adenocarcinomas were positive for ER,ten squamous cell carcinomas,two adenocarcinomas were positive for PR. Conclusion These finding suggest that situation of cytoplasmic ER and PR presence in lung cancers is similar to that in breasts carcinoma,There are more positive cases in the well differentiated tumors than those in the poor differentiated ones. Therefore,the positive rate of ER and PR in the squamous carcinoma was higher (27.6% and 34.5%).That anti-estrogen treatment may offer a new approach to the therapy of lung cancers.