Effect of superoxide dismutase on convulsive seizures in rat models of epilepsy |
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| Authors: | I. V. Gusakov B. P. Sharonov T. I. Oparina D. K. Kambarova |
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| Affiliation: | (1) Department of Clinical Neurobiology, Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg |
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| Abstract: | Intravenous injections of superoxide dismutase into rats with amygdaline kindling mitigated spontaneous and electrostimulation-induced epileptic seizures and raised the thresholds of electric current for their elicitation; these seizures of reduced intensity were observed during 3 days following chronic (for 6 days) treatment with this enzyme. In contrast, superoxide dismutase injections had no effect on the convulsions induced by electric shock or corazole. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N o 7, pp. 20–22, July, 1995 Presented by A. N. Klimov, Member of the Russian Academy of Medical Sciences |
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| Keywords: | epileptic activity amygdaline kindling superoxide dismutase |
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