KAI1/CD82、E-选择素在乳腺癌中的表达及其临床意义

目的　探讨KAI1/CD82与E 选择素在人乳腺癌中的表达及其临床意义。方法　采用免疫组化方法对6 2例乳腺癌和15例乳腺良性病例中KAI1/CD82与E 选择素基因表达的水平进行研究。结果　乳腺癌中KAI1/CD82与E 选择素的表达与良性病变有显著差异(P <0 .0 5 )。KAI1/CD82在腋淋巴结转移组和远处转移组阳性表达率明显低于无腋淋巴结转移组和远处转移组(P <0 .0 5 ) ,生存期≥5年组KAI1/CD82阳性率明显高于生存期<5年组(P<0 .0 5 ) ,与生存期呈正相关。E- 选择素在腋淋巴结转移组和发生远处转移组阳性表达率明显高于无腋淋巴结转移组和远处转移组(P <0 .0 5 ) ,生存期≥5年组E 选择素阳性表达率明显低于生存期<5年组(P <0 .0 5 ) ,与生存期呈负相关。KAI1/CD82和E- 选择素均与临床病理类型、ER、PR、CerbB 2表达状态无关(P >0 .0 5 )。KAI1/CD82与E -选择素表达呈负相关(P <0 .0 5 )。结论　KAI1/CD82与E-选择素在乳腺癌的发生和发展及预后中起着重要作用。检测KAI1/CD82与E- 选择素的表达可能成为监测人乳腺癌进展及临床上判断预后的重要参考指标。

Expression and clinical significance of KAI1/CD82 and E-selectin in breast cancer

Objective To investigate the expression and clinical significance of KAI1/CD82 and E-selectin gene in human breast cancer.Methods The expression of the two protein were investigated by means of immunohistochemistry in 62 cases of breast cancer and 15 cases of breast benign diseases.Results The expression of KAI1/CD82 and E-selectin were significantly different between breast cancer and breast benign diseases(P<0.05).The positive rates of KAI1/CD82 expression in axillary lymph nodes metastasis and distant metastasis group were lower than that of patients without axillary lymph nodes metastasis or without distant metastasis(P<0.05).The positive rates of KAI1/CD82 expression in survival time over 5 years group were more than those in patients survival time under 5 years group(P< 0.05).The positive rates of E-selectin expression in axillary lymph nodes metastasis and distant metastasis group were more than those in patients without axillary lymph nodes metastasis or without distant metastasis(P<0.05).The positive rates of E-selectin expression in survival time over 5 years group were lower than those in patients survival time under 5 years group(P< 0.05).Expression of KAI1/CD82 and E-selectin were not correlated with tumor pathological type,ER,PR,CerbB-2 expression(P>0.05).There was significant difference between KAI1/CD82 and E-selectin expression(P<0.05).Conclusion KAI1/CD82 and E-selectin play an important role in the carcinogenesis,calculating the biological behavior and the prognosis.It is helpful to learn the prognosis by detecting KAI1/CD82 and E-selectin together.