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Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients |
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| Authors: | Eniko Safrany Renata Hobor Laszlo Jakab Tunde Tarr Veronika Csongei Luca Jaromi Csilla Sipeky Andrea Valasek Margit Zeher Gyorgy Fust Laszlo Czirjak Bela Melegh |
| Affiliation: | 1. Department of Medical Genetics, University of Pecs, Szigeti 12, 7624, Pecs, Hungary 2. Department of Immunology and Rheumatology, University of Pecs, Akac 1, 7632, Pecs, Hungary 3. 3rd Department of Internal Medicine, Semmelweis University, Kutvolgyi 4, 1125, Budapest, Hungary 4. 3rd Department of Internal Medicine, Institute for Internal Medicine, University of Debrecen, Moricz Zsigmond 22, 4004, Debrecen, Hungary |
| Abstract: | ObjectiveWe investigated the association between systemic lupus erythematosus (SLE) and polymorphisms of interleukin-23 receptor (IL23R) gene, which was recently found to be associated with autoimmune diseases, including Crohn’s disease, rheumatoid arthritis, psoriasis and ankylosing spondylitis.SubjectsWe analysed 383 SLE patients and 253 controls for rs11805303, rs10889677, rs1004819, rs2201841, rs11209032, 11209026, rs10489629, rs7517847 and rs7530511 variants.MethodsThe analysis was carried out using PCR–RFLP methods. Logistic regression analysis was used to compare the genotype distributions of the polymorphisms and haplotypes between the SLE patients and healthy controls.ResultsWe observed no significant difference of the examined variants between the patient and control groups.ConclusionsOur results suggest that neither single nucleotide variants nor haplotypes of IL23R indicate susceptibility to developing SLE in the Hungarian population. |
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