New aristolochic acid, aristololactam and renal cytotoxic constituents from the stem and leaves of Aristolochia contorta |
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| Authors: | Zhang C Y Wang X Su T Ma C M Wen Y J Shang M Y Li X M Liu G X Cai S Q |
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| Institution: | Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China. |
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| Abstract: | Two novel phenanthrene derivatives, aristololactam IVa (1) and 9-hydroxy aristolochic acid I (2) were isolated from the stem and leaves of Anstolochia contorta Bunge, together with 17 known compounds (3-19). The structures of these compounds were determined by spectroscopic analysis. The phenanthrenes obtained were tested for cytotoxicity against renal proximal tubular epithelial cell line (HK-2). Aristololactam IVa and 7-methoxy aristololactam IV were found to have strong cytotoxic activity against HK-2 cells with a potency similar to or even stronger than those of aristolochic acid I and aristololactam I. |
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