前列地尔治疗糖尿病周围神经病变的临床观察

目的:探讨前列地尔(LipoPGE1,凯时)治疗糖尿病周围神经病变的作用及其不良反应。方法:选取80例糖尿病周围神经病变患者,随机分为治疗组(前列地尔+弥可保组)40例,对照组(弥可保组)40例。两组控制血糖方法相同,对照组给予弥可保500%g肌肉注射,每日1次,观察组给予弥可保500%g肌肉注射和前列地尔10%g静脉滴注,每日一次,两组疗程均为4周,观察其对神经传导速度(SNCV、MNCV)影响。结果:治疗4周后,患者主观症状和体征有较明显改善,前列地尔注射液治疗糖尿病周围神经病变总有效率为82.5%,对照组总有效率为55.0%,两组疗效比较,有显著差异性(P<0.01)。同时改善神经传导速度,两组疗效比较,有显著差异性(P<0.01)。药物治疗过程中未见明显的不良反应。结论:前列地尔注射液是治疗糖尿病神经病变安全且有效的药物。

Study of efficacy on Lipo PGE1 in treatment of diabetic peripheral neuropathy

Objective To observe the effects of Lipo PGE1 in the treatment of diabetic neuropathy and side reactions. Method 80 patients with early diabetic neuropathy were divided randomly into the treatment group with PGE1 10μg and Lethycobal 500μg daily for 4 weeks,and the Lethycobal group with Lethycobal 500μg daily for 4 weeks in order to observe nerve conduction velocity. Results After treatment for 4 weeks,the subjective symptoms and signs were significantly improved with a total effective rate of 82.5%in the treatment group versus 55%in the control group,Compared with the Lethycobal group,the total effective rates of treatment group was significantly higher (P<0.01),and improveds ignificantly nerve conduction velocity(P<0.01).No obvious adverse drug reactions were observed. Conclusion Lipo PGE1 is an effective and safe agent for treatment of diabetic peripheral neuropathy.