肥胖与非肥胖型多囊卵巢综合征患者血清C反应蛋白水平及意义

目的]探讨肥胖与非肥胖型多囊卵巢综合征(PCOS)患者血清中C反应蛋白(CRP)的变化及与胰岛素抵抗的关系。方法]将56例PCOS患者按体重指数(BMI)分为非肥胖PCOS组(22例)和肥胖PCOS组(34例),46例正常妇女分为非肥胖对照组(19例)和肥胖对照组(27例)。测定血清卵泡刺激素(FSH)、黄体生成素(LH)、泌乳素(PRL)、雌二醇(E2)、睾酮(T)、空腹血糖(FPG)、空腹胰岛素(FINS)、CRP浓度。结果]PCOS组LH、LH/FSH、T、FINS显著高于对照组,胰岛素敏感指数(ISI)显著低于对照组,两组CRP水平无统计学差异。肥胖PCOS组和肥胖对照组血清CRP水平均显著高于各自的非肥胖组。血清CRP水平与BMI、FINS呈正相关,与ISI呈负相关。结论]PCOS患者不存在慢性亚临床炎症,心血病风险仅限于合并肥胖或胰岛素抵抗的PCOS患者。

SIGNIFICANCE AND LEVEL OF C REACTIVE PROTEIN IN THE SERUM OF OBESITY AND NON-OBESITY PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME

Objective To investigate the concentration of CRP in polycystic ovary syndrome(PCOS) with or without obesity and its relation to insulin resistance and obesity.Methods 56 patients with PCOS(non-obese PCOS group, 22 cases;obese PCOS group, 34 cases) and 46 healthy women(non-obese control group, 19 cases;obese control group, 27 cases) were selected.FSH, LH, PRL, E2, T, fasting insulin(FINS) , fasting plasma glucose(FPG) and CRP level were measured.Results LH, LH / FSH, T and FINS in patients with were significant higher than those in controls;Insulin sensitive index(ISI) in PCOS was significantly lower compared with controls.The CRP levels in serum of obese PCOS and obese control groups were significantly higher than the non-obesity groups.CRP showed positive association with BMI and FINS, and negative association with ISI.Conclusion There was no low grade chronic inflammation in patients with PCOS.In patients with PCOS, the CVD risk may be associated with obesity or / and insulin resistance people.