银杏达莫针剂对急性肺损伤兔肺组织氧自由基的影响

目的观察银杏达莫针剂对油酸所致急性肺损伤氧自由基的影响。方法 24只家兔随机分为3组:假手术组、油酸模型组及银杏达莫治疗组,每组8只。连续监测并记录造模前、造模和治疗后1、2、3、4 h的心率、平均动脉压的变化;实验结束时测定肺组织湿、干重量,计算湿/干重比,并取肺组织检测丙二醛(MDA)和超氧化物歧化酶(SOD)。结果银杏达莫组外周血管阻力降低;银杏达莫组与模型组比较,可以降低MDA(p<0.05)和升高SOD(p<0.05),减轻肺组织湿/干比(p<0.05)。结论银杏达莫针剂可减轻油酸所致急性肺损伤的氧化应激作用。

EFFECTS OF GINKGO DIPYRIDOLUM INJECTION ON OXYGEN FREE RADICALS OF THE LUNG TISSUE IN RABBITS WITH ACUTE LUNG INJURY

Objective To observe the effects of Ginkgo dipyridolum injection on oxygen free radicals in rab- bits with acute lung injury （ALI） induced by oleic acid （OA）. Methods 24 rabbits were randomly divided into three groups： sham operation group, OA model group and ginkgo dipyridolum （GLE -DD） group in equal number. The changes of the heart rate and mean arterial pressure （MAP） before and after making model and at hours 1,2, 3 and 4 after treatment were constantly monitored and recorded. At the end of the experiment, the wet weight and dry weight of the lung tissue was detected to count wet -to -dry （W/D） weight ratio. The MDA and SOD in the lung tis- sue were tested. Results The peripheral vascular resistance was decreased in GLE - DD group. In comparison with the model group, the level of MDA was decreased （p 〈0.05） and the level of SOD was increased（p 〈0.05） in GLE - DD group. The W/D weight ratio of the lung tissue was reduced in GLE - DD group （p 〈 0.05 ）. Conclusion Ginkgo dipyridolum injection can alleviate the oxidative stress in OA - induced ALI.