| 曲克芦丁的镇痛作用研究 |
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| 引用本文： | 张晨峥,毛甜甜,姜鸣,叶惟虎,胡璇,敖英,汪晖. 曲克芦丁的镇痛作用研究[J]. 医学新知杂志, 2005, 15(3): 31-32,35 |
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| 作者姓名： | 张晨峥 毛甜甜 姜鸣 叶惟虎 胡璇 敖英 汪晖 |
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| 作者单位： | 武汉大学医学院药理学系,武汉,430071 |
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| 摘 要： | 目的 研究曲克芦丁的镇痛作用。方法 采用醋酸诱发小鼠扭体反应和小鼠热板法。结果 0．30g／kg和0．60g，kg剂晕的曲克芦丁叮明显减少醋酸诱发的小鼠扭体反应次数，延长扭体反应潜伏期，高剂量显著降低扭体发生率：但0．15～0．60g／kg剂量不能提高热板法模型中小鼠痛阈。结论 曲克芦丁具有一定的镇痛作用。
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| 关 键 词： | 曲克芦丁 镇痛 小鼠疼痛模型 镇痛作用 作用研究 小鼠热板法 扭体反应 反应潜伏期 高剂量 发生率 |
| 收稿时间： | 2004-11-08 |
| 修稿时间： | 2004-11-08 |
Analgesic Action of Troxerutin in Mice |
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| Zhang ChenZheng;Mao TianTian;Jiang Ming;Xie WeiHu;Hu Xuan;Ao Ying;Wang Hui. Analgesic Action of Troxerutin in Mice[J]. Journal of New Medicine, 2005, 15(3): 31-32,35 |
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| Authors: | Zhang ChenZheng Mao TianTian Jiang Ming Xie WeiHu Hu Xuan Ao Ying Wang Hui |
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| Abstract: | Objective To investigate the analgesic effect of Troxerutin (TRO). Methods Analgesic effect was studied using experimental pain models induced by acetic acid and hot plate in mice. Results The frequency of wringing reaction induced by acetic acid was significantly decreased and the latent period was prolonged when TRO was administered (0.30 and 0.60 g/kg). The incidence rate of wringing reaction was also reduced at the dose of 0.60 g/kg. Where the latent period in hot plate test wasn't prolonged when TRO was administered at the doses of 0.15 g/kg to 0.60 g/kg. Conclusion TRO possesses significant analgesic action. |
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| Keywords: | troxerutin analgesic effect pain model in mice |
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