老年胃癌患者预后多因素分析

目的 :研究影响老年胃癌预后的独立因素。方法 :采用单因素 ,Kaplan meier生存曲线及COX多因素回归分析了 92例老年胃癌患者临床病理因素及治疗措施对预后的影响。结果 :单因素分析表明 ,老年胃癌预后与血小板计数、体重、肿瘤大小、浸润深度、淋巴结转移及TNM分期有关 (P <0 .0 5 ) ,COX多因素回归分析表明TNM分期、淋巴结转移和血小板增多是影响老年胃癌预后的独立因素 ,TNM分期Ⅰ期、无淋巴结转移和血小板≤ 30×10 12 /L的 5年生存率分别为 91.2 %、92 .3%、86 .7% ,而Ⅳ期、淋巴结转移和血小板 >30× 10 12 /L的 5年生存率分别为 4 1.7%、4 4 .4 4 %、5 0 % (P <0 .0 1) ,根治性手术仍是影响胃癌预后的重要因素。结论 :TNM分期、淋巴结转移和血小板增多是影响老年胃癌预后的独立因素。

Significant prognostic factors by multivariate analysis in elder patients with gastric cancer

Objective:The aim of this study was to indentify and measure the prognostic factors in elder patients with gastric cancer.Methods:Univariate and multivariate analyses of the prognostic value of Various pathological and treatment variables in 92gastric cancer. Survival was compared by using the log-rank test on the kaplan-meier life table.Results:On univariate analysis,significant prognostic factors were plt,Weight,size of tumour,depth of invasion,lymph node metastasis,histologic differentiation and TNM stage(P<0.05),On multivariate analysis,independent prognostic factors were TNM stage,lymph node metastasis and thrombocytosis(P<0.01),The radical gastrectomies is recommended to lengthen survival in elder patients with gastric cancer.Conclusion:TNM stage,lymph node metastasis and thrombocytosis are independent prognostic indicator of survival in elder patients with gastric cancer.