Plasma ferritin and type 2 diabetes mellitus: a critical review. |
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Authors: | I Eshed A Elis M Lishner |
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Institution: | Department of Medicine, Meir Hospital, Kfar Saba and Sackler Faculty of Medicine, Tel-Aviv University, Israel. |
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Abstract: | Multiple factors appear to be involved in the pathogenesis of type 2 (non insulin dependent) diabetes mellitus (DM). One of these factors may be iron overload. This critical review summarizes the major studies on the link between type 2 DM, insulin resistance, glycemic control, diabetic complications and hyperferritinemia. Although some studies suggested that plasma ferritin concentration is positively correlated with insulin resistance and with the risk of acquiring type 2 DM, substantial iron overload is not a typical feature of DM. There is no correlation between plasma ferritin level and glycemic control or diabetic microangiopathic complications. |
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