大肠腺瘤性息肉癌变因素分析

目的：探讨大肠腺瘤性息肉发生癌变的相关因素。方法：对经结肠镜及病理检查确诊的1025例大肠腺瘤性息肉病例发生癌变的相关因素进行回顾分析。结果：1025例中39例发生癌变，癌变率为3．8％。重度不典型增生和癌变的发生率，在≥40岁组显著高于＜40岁组(P＜0．05)，且与息肉的部位、大小及病理类型均显著相关(均P＜0．05)。息肉的直径与重度不典型增生及癌变率呈正比。结论：大肠腺瘤性息肉癌变与其大小、部位、病理类型及患者的年龄等因素相关。

A study on the cancerization factors of colorectal adenomatous polyp

Objective:To investigate the factors associated with the cancerization of colorectal adenomatous polyp. Methods: To analyze the information of 1025 colorectal adenomatous polyp cases which were diagnosed by colonoscopy and pathology. Results: In all cases, the rate of cancerization was 3.8% (39 cases). As far as the rate of cancerization concerned, patients above 40 years old had a higher rates than those who less than 40. The female had a higher rate than the male. The rectal adenoma were more easy to change to malignacy than colon. The diameters of polyp had a positive correlation with cancerization. From the standpoint of pathology, the villous adenoma was more prone to develop into carcinoma than the tubular adenoma. Conclusion: Many factors, such as patient's age, the diameter and location of the polyp, were related to colorectal cancerization. The pathology pattern also played a role in it.