Polyamine dendrimer-based MRI contrast agents for functional kidney imaging to diagnose acute renal failure |
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Authors: | Kobayashi Hisataka Jo Sang-Kyung Kawamoto Satomi Yasuda Hideo Hu Xuzhen Knopp Michael V Brechbiel Martin W Choyke Peter L Star Robert A |
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Affiliation: | Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Kobayash@mail.nih.gov |
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Abstract: | PURPOSE: To choose an efficacious renal functional MRI contrast agent to image early renal tubular damage. We synthesized and compared smaller polyamine dendrimer-based MRI contrast agents (<60 kD) that, unlike Gd-[DTPA], transiently accumulate in renal tubules and can be used to visualize renal structural and functional damage. MATERIALS AND METHODS: Six dendrimer-based MRI contrast agents smaller than 60 kD were studied by high resolution dynamic micro-MRI and compared to Gd-[DTPA]-dimeglumine and Gadomer-17. The best agent, DAB-G2, was further tested in a mouse ischemia/reperfusion model to validate its efficacy. RESULTS: Despite unequal renal clearance rates, all polyamine dendrimer agents visualized the renal functional anatomy of the mice better than Gd-[DTPA]-dimeglumine and Gadomer-17. DAB-G2 was excreted most rapidly, yet was able to visualize mild renal tubular injury very early after injury. CONCLUSION: DAB-G2 was found to be the best candidate for functional kidney imaging and enabled early diagnosis of acute renal injury. |
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Keywords: | magnetic resonance imaging kidney polyamine dendrimer contrast media acute renal failure |
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