中药治疗慢性乙型重型肝炎内毒素血症80例临床观察

目的:观察中药治疗慢性乙型重型肝炎内毒素血症的临床疗效及安全性。方法:随机将160例慢性乙型重型肝炎内毒素血症患者分为治疗组、对照组各80例,对照组仅运用西药治疗,治疗组在对照组基础上口服中药结合中药保留灌肠,两组均治疗4周。结果:治疗组治疗前后血液细菌内毒素(ET)、血氨、血清总胆红素(TBIL)和凝血酶原活动度(PTA)改善明显优于对照组(P0.05);治疗组患者存活率与对照组相比有显著性差异(P0.05)。结论:口服中药结合中药保留灌肠治疗慢性乙型重型肝炎内毒素血症能显著降低血内毒素,改善肝功能,提高存活率;中药未出现不良反应,较为安全。

Clinical observation on treating 80 cases of endotoxemia in chronic severe hepatitis B in TCM

Objective: To observe the efficacy and safety of TCM on treating endotoxemia in chronic severe hepatitis B.Methods: 160 cases of chronic severe hepatitis B patients with endotoxemia were randomly divided into treatment group and control group,80 cases in each group,the control group were treated with western medicine,the treatment group were given oral medicine and TCM retention enema on the basis of treatment in the control group,two groups were treated for 4 weeks.Results: Before and after treatment,the blood bacterial endotoxin(ET),ammonia,total serum bilirubin(TBIL) and prothrombin activity(PTA) of treatment group were improved than that in the control group(P<0.05);the survival rate of the control group was significant difference(P<0.05) comparing with treatment group.Conclusion: The oral medicine combining with the Guanchang decoction can retain the enema in the treatment of chronic severe hepatitis B,and significantly reduce blood endotoxin and improve liver function and survival rate;TCM does not appear to adverse reactions,that is safe.