持续皮下胰岛素输注在儿童糖尿病患者中应用的有效性和安全性

持续皮下胰岛素输注(CSII)是1型糖尿病患儿的理想选择,它能降低血糖波动幅度、持续降低糖化血红蛋白、减少胰岛素用量,配合使用胰岛素类似物时效果更佳。同时,CSII治疗并不增加低血糖及酮症酸中毒等急性并发症的发生,在年幼患儿中甚至明显减少低血糖的发生,又能保持体质量稳定。CSII应用于各年龄段的1型糖尿病患儿是安全有效的,亦可用于糖代谢控制不佳的2型糖尿病患儿,有效性和安全性与每日多次注射方案(MDI)无明显差别。

Efficacy and Safety of Continuous Subcutaneous Insulin Infusion in Diabetic Children YANG Yu1,

It is crucial for clinicians and parents to have tight control over the children′s metabolism and ensure their normal growth and development.The invention with insulin pump is an ideal choice for continuous subcutaneous insulin infusion(CSII)to achieve the therapeutic goals.It can obviously improve the glycemic control but diminish the glucose variation and insulin dose,especially when using insulin analogue.There is no statistical difference in the incidence of hypoglycemia and ketoacidosis in CSII compared to multiple daily injection(MDI),so does the body mass index(BMI).The occurrence of hypoglycemia in infants with type 1 diabetes is even much lower.Although insulin pump therapy can also be used in type 2 diabetic children with poor glycemic control,there is no difference in the incidence of hypoglycemia and ketoacidosis due to the limited literatures.