Pemphigus antibody induced phosphorylation of keratinocyte proteins |
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Authors: | Rubenstein David S Diaz Luis A |
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Institution: | Department of Dermatology, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599-7287, USA. druben@med.unc.edu |
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Abstract: | The pemphigus family of autoimmune blistering diseases is characterized by an autoantibody response to desmosomal cadherins in epithelia. Autoantibodies against desmogleins, desmosome cell adhesion molecules, induce loss of cell-cell adhesion that is characterized clinically by blister formation. The mechanism by which these autoantibodies induce loss of cell-cell adhesion is under active investigation, but appears to involve a coordinated intracellular response including activation of intracellular signaling and phosphorylation of a number of proteins in the target keratinocyte. Activation of p38 mitogen activated protein kinase may have a critical role in the acantholytic mechanism as inhibitors of p38MAPK block the ability of pemphigus IgG to induce blistering in pemphigus animal models. |
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