喉癌单纯放疗后原发灶复发的救援治疗

目的：探讨对喉癌单纯放疗后原发灶复发进行挽救治疗的疗效。方法：回顾52例1990年-1995年于中山大学肿瘤防治中心进行单纯放疗的喉癌患者，其中17例治疗后原发灶复发的患者进行总结。5例患者进行姑息性化疗，另外12例患者行手术挽救，6例行喉部分切除术，6例行喉全切除术。应用SPSS10．0统计软件进行分析。结果：单纯放射治疗后原发灶复发经再次挽救治疗后总体三年和五年累计生存率分别为56．3％和37．5％。其中进行姑息化疗的患者经挽救后的生存时间介于8～26个月，进行手术挽救的患者三年和五年累计生存率分别为75％和50％，Kaplan—Meier分析表明两者之间存在显著差异(Log Rank=8．14，P=0．0043)。另外，进行手术挽救的患者中，喉部分切除术和喉全切除术挽救患者的五年累计生存率均为50％，Kaplan-Meier分析显示两者间无显著差异(Log Rank=0．08，P=0．7782)。12例进行手术挽救的患者中5例(41．7％)出现术后并发症，主要是术后感染(25％)和咽瘘(25％)。结论：喉癌单纯放疗后原发灶复发患者进行手术挽救可以获得较好的疗效。原发灶早期(T1和T2)患者复发后可选择进行喉部分切除术挽救。手术挽救后的并发症主要是术后感染和咽瘘。

Salvage treatment of primary recurrence in patients with laryngeal cancer after definitive radiotherapy

Purpose:To investigate the clinical applicati on and curative effect of salvage treatment for primary recurrence after definitiv e radiotherapy in patients with laryngeal cancer. Methods:52 patients with laryngeal cancer receiving definitive radiotherapy in the Cancer Center of Sun Yat-sen University between 1990 and 19 95 were reviewed retrospectively. Among them, 17 patients presented with primary recurrence. Salvage treatment after radiotherapy failure included palliative ch emotherapy (5 cases) and surgical salvage (12 cases). 6 patients were salvaged b y partial laryngectomy and 6 patients by total laryngectomy. SPSS 10.0 software was used to analyze the effects, complications and the differences between diffe rent salvage treatments. Results:The overall 3- and 5-year cumulative survival rates a fter salvage treatment for primary recurrence in patients with laryngeal cancer receiving definitive radiotherapy were 56.3% and 37.5% respectively. The patient s receiving palliative chemotherapy after radiotherapy failure survived between 8 and 26 months. The 3- and 5-year cumulative survival rate in patients receiv ing surgical salvage were 75% and 50% respectively. There was significant differ ence between them analyzed by Kaplan-Meier (Log Rank=8.14, P=0.004 3). More over, the 5-year survival rates in patients salvaged by partial laryngectomy an d total laryngectomy were all 50% and there was no statistical difference betwee n them (Log Rank=0.08, P=0.7782). 5 out of 12 (41.7%) patients salvaged by s urgery presented complication after surgery, mainly infection after surgery (25 %) and pharyngocutaneous fistula (25%). Conclusions:Surgical salvage for primary recurrence in patients with laryngeal cancer receiving definitive radiotherapy could be effective.Part ial laryngectomy could be used for early primary lesion (T 1 and T 2) in patie nts with primary recurrence. The complications after salvage surgery were mainly were infection and pharyngocutaneous fistula.