测定血清CA125水平在卵巢癌的临床意义

目的分析卵巢癌手术前后测定血清CA125水平的临床意义.方法采用回顾性分析方法,1994年1月～2000年8月我院收治的137例卵巢癌患者手术前后血清CA125水平结合病理、分期、分化、手术情况治疗及预后等临床资料进行分析.结果在卵巢癌,术前血清CA125水平与病理类型及分期相关(P=0.006),术后2～4个月血清CA125水平与手术的癌细胞减灭程度相关(P=0.025),术后5～7个月血清CA125水平与是否坚持化疗相关(P=0.014),且为预测复发及生存时间的重要因素.术后血清CA125水平的升高可预测复发,其敏感性为87.5%,且通常较临床证实复发提前,平均为7.2个月.结论卵巢癌患者术前测定血清CA125水平可初步反映病理类型及分期,术后监测血清CA125水平可反映手术的肿瘤减灭程度,及时预测复发,并可判断预后.

The clinical significance of the serum CA125 level in ovarian cancer

Objective To evaluate the clinical significance of the serum CA125 level before and after operation of ovarian cancer. Methods 137 patients with ovarian cancer underwent operation in First hospital between January 1994 and August 2000. Correlation analyes among the serum CA125 level and histological type, FTCO stage, cell differentiation, extent of cytoreduc-tion, number of chemotherapy courses, time of recurrence and survival rate were carried out retrospectively. Results The serum CA125 level before operation was related to histological type and FIGO stage (P= 0.006) . The level at 2-4 months after operation was related to the extent of cytoreduction ( P = 0.025) . The level at 5 - 7 months after operation was related to the number of chemotherapy courses and It was also the independent prognostic variable. The increase of the serum CA125 level after operation usually indicated recurrence with asensitivity of 87.5% and the change often occurred 7.2 months (in average) than clinical recurrence. Conclusions The serum CA125 level before operation of ovarian cancer can help to know the histological type and FIGO stage. This marker is useful in the early detection of recurrence. Monitoring it changes after operation can provide the information about the extent of cytoreduction and predict time of recurrence and survival rate.