自由基和抗氧化剂生态网络系统理论模型及应用研究

目的 试图从理论上提出自由基和抗氧化剂生态网络系统理论模型,建立统一的自由基和抗氧化剂生物效应理论模型,解释和定量描述自由基、抗氧化剂生物效应的双相性或多样性,并应用于核化生损伤的医学防护等研究。方法 在总结自由基生物医学最新成果的基础上,提出有关自由基和抗氧化剂的10个基本原理,建立统一的自由基和抗氧化剂生态网络系统理论模型。结果 提出自由基和抗氧化剂生态网络系统理论模型,建立了3个自由基和抗氧化剂生态网络系统理论模型方程,可以解释和定量描述自由基和抗氧化剂生物效应的双相性或多样性,并提出了核化生损伤的统一的氧化还原应激损伤机理和防护措施。结论 提出自由基和抗氧化剂生态网络系统理论模型,解释和定量描述自由基和抗氧化剂生物效应的双相性或多样性。该理论模型适用于其他广义刺激的氧化还原应激:物理因子、化学因子、生物因子、心理、药物、毒物毒素等,可称为广义氧化应激和还原应激的生态网络系统理论模型。

Study on Free Radical and Antioxidant Ecological Network System Theory Model and Its Application

Objective To put forward and establish a unified theory of free radicals and antioxidants bilolgieal effect model to quantitatively describe and explain biphase of diversity of the bilolgieal effects of free radicals and antioxidant, and apply to the medical protection in NCB damage. Methods Summarize the latest achievements in free radicals and antioxida nts in biomedical, put forward 10 basic principles to establish the unified theory of free radicals and antioxidants eclolgical net work system model. Results Free radicals and antioxidants ecological network system theory model is proposed and 3 model equations are established, they can quantitatively describe and explain the biphase or diversity biological effects of free radicals and antioxidants, and put forward the unified stress damage mechanism and protective measures induced by NCB damage. Conclusion Free radicals and antioxidants ecological network system theory and the model can quantitativerly describe and explain the biploar or diversity biological effects of free radicals and antioxidants, can also be applied to other generalized stress stimulus： physical factors, chemical factors and bilolgical factors, psychological, drugs, poisons, etc. This is a general ized ecological network stystem theory model for oxidative stress and redox stress.