多种营养素联合应用对儿童铅中毒影响

目的 探讨多种营养素联合应用对铅毒性的拮抗作用。方法 采用自身对照及组间对照法,对维生素C、维生素B1及钙、铁、锌、硒6种已知对铅毒性有拮抗作用的营养素进行人体干预研究。结果 试验组血铅平均值由(160.4±29.2)μg/L下降为(125.8±20.1)μg/L;尿铅平均值由(30.4±8.5)μg/L增加为(39.6±11.6)μg/L;与试食前和对照组比较,试食组试食后血铅下降及尿铅排出差异均有统计学意义(P<0.01);试食组相同时间点尿铅排出率高于尿钙、尿锌的排出率(P<0.05),且临床症状有较明显改善(P<0.05)。结论 多种营养素联合应用具有拮抗儿童铅中毒的作用。

Joint effects of nutrients on lead poisoning in children

Objective To explore the jointe ffects of nutrients against the toxicity of lead.Methods With self-com parison and group-comparison design,six nutrients were tested in a clinical intervention trial.The nutrients were vitam in C, vitam in B₁,calcium,iron,zinc,selenium,which have effects of against lead toxicity.Results On the avrage,the nutrients could reduce blood lead from 160.4±29.2 μg/L to 125.8±20.1 μg/L and increase urine lead from 30.4±815 μg/L to 39.6±11.6 μg/L in the experimental group.After the experiment,the experimental group showed significant differences compared with itself and the control group in the descent of blood lead and the elmiination of urine lead(P < 0.01).The elmiination ratio of urine lead was higher than that of urine calcium and urine zinc in the expermiental group on the same tmie point(P < 0.05).The nutrients relieved clinical symptoms of the patients(P < 0.05).Conclusion The joint effects of nutrients against lead poisoning could be achieved by jointadm in istration in children.