T cell receptor specificity for major histocompatibility complex proteins |
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Authors: | Marrack Philippa Rubtsova Kira Scott-Browne James Kappler John W |
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Affiliation: | Howard Hughes Medical Institute, National Jewish Medical and Research Center, Denver, Colorado 80206, USA. marrackp@njc.org |
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Abstract: | The ligands for alpha beta T cell receptors (alphabetaTCRs) are usually major histocompatibility complex (MHC) proteins bound to peptides. Although there is evidence that T cell receptor variable regions have been selected evolutionarily to bind MHC, the rules governing this interaction have not previously been apparent. However, recent solved structures of T cell receptors with related variable regions bound to MHC plus peptides suggest that some amino acids in variable region CDR1 and CDR2s almost always react in a consistent way with MHC. These amino acids may therefore have been selected evolutionarily to predispose T cell receptors toward recognition of MHC ligands. |
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