糖尿病肾病患者D-二聚体和纤维蛋白原检测的应用价值

目的探讨血浆D-二聚体(DD)和纤维蛋白原(Fig)在糖尿病肾病(DN)患者中的变化及应用价值。方法根据尿白蛋白排泄率(UAER),将98例2型糖尿病(DM)患者分为单纯糖尿病组(SDM组)、早期糖尿病肾病组(EDN组)和临床糖尿病肾病组(CDN组),30例健康者作为对照组,分别测定各组血浆DD和Fig的水平。结果各糖尿病组与健康对照组比较,DD、Fig水平差异均具有统计学意义(P<0.05),EDN和CDN组显著高于SDM组(P<0.05),CDN组显著高于EDN组(P<0.01)。DD和Fig分别与UAER呈显著正相关(r=0.469及0.392,P<0.01)。结论DN患者血浆DD和Fig水平随着UAER的增加而升高,两者之间关系密切,可能与DN的进展有关。

Application of plasma D-dimer and fibrinogen levels in patients with diabetic nephropathy

Objective To investigate the relationship of D-dimer(DD) and fibrinogen levels in blood plasma and diabetic nephropathy(DN).Methods According to the results of urinary albumin excretion rate (UAER), 98 cases of type 2 diabetas were divided into simple diabetic mellitus ( SDM), early diabetic nephropathy ( EDN) and clinical diabetic nephropathy (CDN); other 45 healthy persons were employed as control. Plasma levels of DD and the fibrinogen of all groups were examined.Results There was significant difference of DD and fibrinogen levels in all groups as compared with control group (P< 0. 05).DD and fibrinogen levels in EDN and CDN groups were significantly higher than those in SDM and control groups (P< 0. 01), and those in CDN were significantly higher than in EDN. DD and fibrinogen were positively correlated in straight line with UAER(r=0.469,0.392,P<0. 01).Conclusion The levels of DD and fibrinogen in DN increase with the increment of UAER. They have a close relationship. Increment of DD and fibrinogen might be related to the progression of DN.