| 骨髓增生异常综合征基因缺陷的研究 |
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| 引用本文： | 冯海峰,郁知非.骨髓增生异常综合征基因缺陷的研究[J].中国实验血液学杂志,2000,8(1):71-74. |
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| 作者姓名： | 冯海峰 郁知非 |
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| 作者单位： | 暨南大学医学院血液病研究室,广州,510632 |
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| 摘 要： | 骨髓增生异常综合征是一种造血干细胞克隆异常性疾病。近代分子遗传学的发展使我们其分子水平上的形成机制有了进一步的了解。本主要从原癌基因的异常表达、肿瘤抑制基因表达的缺失和ＤＮＡ修复机制的异常等方面概括地论述了骨髓增生异常综合征基因缺陷的研究进展。
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| 关 键 词： | 骨髓增生异常综合征 基因缺陷 癌基因 |
| 修稿时间： | 1999年8月11日 |
Study on Gene Defects in Myelodysplastic Syndrome |
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| FENG Haifeng,YU Zhifei.Study on Gene Defects in Myelodysplastic Syndrome[J].Journal of Experimental Hematology,2000,8(1):71-74. |
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| Authors: | FENG Haifeng YU Zhifei |
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| Abstract: | Myelodysplastic syndrome (MDS) is a clonal disorder of the hematopoietic stem cell. Recent developments in molecular genetics have provided insights into the molecular mechanisms that lead to MDS. This review summarizes the most recent developments in the understanding of the gene defects associated with MDS which mainly include altered expression of oncogenes, the loss of expression of tumor suppressor genes and the repair of DNA. |
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| Keywords: | myelodysplastic syndrome gene defect oncogene tumor suppressor gene |
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