Serum carbonic anhydrase III in progressive muscular dystrophy |
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Authors: | K Mokuno S Riku Y Matsuoka I Sobue K Kato |
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Institution: | 1. First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya Japan;2. Department of Biochemistry, Institute for Developmental Research, Aichi Prefectural Colony, Kasugai, Aichi Japan |
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Abstract: | Serum carbonic anhydrase III (CA-III) levels were determined by means of an enzyme immunoassay method and compared with serum creatine kinase (CK) and muscle-specific enolase (MSE) levels in 143 patients with four types of progressive muscular dystrophy (PMD), namely, Duchenne muscular dystrophy (DMD), limb-girdle dystrophy, facioscapulohumeral dystrophy and congenital dystrophy. Serum CA-III levels were raised in the majority of patients, especially in those with DMD. In DMD patients, the gradual decline in the CA-III level was observed with age. High correlations were found between CA-III, CK and MSE levels. The frequency of cases with elevated CA-III levels was the same as or greater than that of elevated CK or MSE levels in four types of PMD. These results suggest that serum CA-III may be a useful marker of muscle disease. |
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Keywords: | Carbonic anhydrase III Creatine kinase Muscle-specific enolase Progressive muscular dystrophy |
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