| 海洋生物表面活性肽小鼠急性毒性实验 |
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| 引用本文： | 符大勇,邓婧,孙德刚. 海洋生物表面活性肽小鼠急性毒性实验[J]. 齐鲁医学杂志, 2011, 26(6): 544+546 |
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| 作者姓名： | 符大勇 邓婧 孙德刚 |
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| 作者单位： | 1. 青岛市口腔医院牙体牙髓科,山东青岛,266001
2. 青岛大学医学院附属医院口腔内科 |
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| 摘 要： | 目的 观察海洋生物表面活性肽(SRP)的安全性.方法 取昆明种小鼠40只,随机分为对照组和实验组,每组20只,实验组每只小鼠给予113.3 g/kg的SRP灌胃1次,给药体积为50 mL/kg,对照组给予等体积生理盐水,观察小鼠的死亡率和脏器的大体病理改变.结果 实验组20只小鼠观察14 d无1例死亡,亦无任何异常及...
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| 关 键 词： | 海洋生物表面活性肽 急性毒性试验 小鼠 |
EFFECT OF SURFACE BIOACTIVE PEPTIDE OF MARINE LIFE ON MICE: AN ACUTE TOXICITY TEST |
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| FU Dayong,DENG Jing,SUN Degang. EFFECT OF SURFACE BIOACTIVE PEPTIDE OF MARINE LIFE ON MICE: AN ACUTE TOXICITY TEST[J]. Medical Journal of Qilu, 2011, 26(6): 544+546 |
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| Authors: | FU Dayong DENG Jing SUN Degang |
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| Affiliation: | FU Dayong,DENG Jing,SUN Degang(Department of Endodontics,Qingdao Stomatological Hospital,Qingdao 266001,China) |
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| Abstract: | Objective To observe the safety of surface bioactive peptide(SBP) of marine life.Methods Forty Kunming mice were equally randomized to control group and experimental group.One single dose of SBP(113.3 g/kg)-with a medication volume of 50 mL/kg was given to each of the mouse in experimental group,intragastrically;to those in the control,an equal-volume normal saline was offered.The mortality and pathologic changes of organs of the mice were observed.Results A follow up of 14 days showed neither death nor int... |
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| Keywords: | surface bioactive peptide of marine life acute toxicity tests mice |
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