Depletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats |
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| Affiliation: | 1. Department of Psychiatry, Medical University of Białystok, Plac Brodowicza 1 Str., 16-070 Choroszcz, Poland;2. Department of Conservative Dentistry, Medical University Bialystok, M. Skłodowskiej-Curie 24A Str., 15-276 Białystok, Poland;3. Medical College of the Universal Education Society, Mickiewicza 59 Str., 18-400 Łomża, Poland;4. Department of Psychiatry, Medical University of Warsaw, Partyzantów 2/4 Str., 05-802 Pruszków, Poland;1. Baylor College of Medicine, Houston, TX, USA;2. University of Ottawa, Ottawa, ON, Canada;3. El Camino Urology, Mountain View, CA, USA;4. University of Utah, Salt Lake City, UT, USA;5. Urology Centers of Alabama, Birmingham, AL, USA;6. Urology Team, Austin, TX, USA;7. Urology San Antonio, San Antonio, TX, USA;8. SIU School of Medicine, Carbondale, IL, USA;9. Lahey Clinic, Burlington, MA, USA;10. Kaiser Permanente, Oakland, CA, USA;11. Regional Urology, Shreveport, LA, USA;1. University of Wisconsin-Madison, School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, USA;1. Department of Psychopharmacology, Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Croatia;2. University Psychiatric Hospital Vrapce, Zagreb, Croatia;3. Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia;4. Department of Psychiatry, Referral Centre for the Stress related Disorders of Ministry of Health of Croatia, University Hospital Dubrava, Zagreb, Croatia |
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| Abstract: | During adulthood, neuronal precursor cells persist in two discrete regions, the subventricular zone[19]and the hippocampal subgranular zone,[11]as recently demonstrated in primates.[10]To date, a few factors such as adrenal steroids[9]and trophic factors[13]are known to regulate adult neurogenesis. Since neuronal activity may also influence cellular development and plasticity in brain, we investigated the effects of serotonin depletion on cell proliferation occurring in these regions. Indeed, in addition to its role as a neurotransmitter, 5-hydroxytryptamine (serotonin) is considered as a developmental regulatory signal.14, 22Prenatal depletion in 5-hydroxytryptamine delays the onset of neurogenesis in 5-hydroxytryptamine target regions[14]and 5-hydroxytryptamine promotes the differentiation of cortical and hippocampal neurons.15, 23Although in the adult brain, a few studies have suggested that 5-hydroxytryptamine may play a role in neuronal plasticity by maintaining the synaptic connections in the cortex and hippocampus,3, 6, 16no information is actually available concerning the influence of 5-hydroxytryptamine on adult neurogenesis. If further work confirms that new neurons can be produced in the adult human brain as is the case for a variety of species, it is particularly relevant to determine the influence of 5-hydroxytryptamine on neurogenesis in the hippocampal formation, a part of the brain largely implicated in learning and memory processes. Indeed, lack of 5-hydroxytryptamine in the hippocampus has been associated with cognitive disorders, such as depression,[1]schizophrenia and Alzheimer's disease.[7]In the present study, we demonstrated that both inhibition of 5-hydroxytryptamine synthesis and selective lesions of 5-hydroxytryptamine neurons are associated with decreases in the number of newly generated cells in the dentate gyrus, as well as in the subventricular zone. |
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