| 内皮素和降钙素基因相关肽对异丙肾上腺素致心肌损伤的影响 |
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| 引用本文： | 谭敦勇 张继峰. 内皮素和降钙素基因相关肽对异丙肾上腺素致心肌损伤的影响[J]. 心肺血管病杂志, 1994, 13(1): 43-44 |
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| 作者姓名： | 谭敦勇 张继峰 |
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| 作者单位： | 北京医科大学心肺内分泌研究室 |
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| 摘 要： | 本实验在大鼠异丙肾上腺素（ＩＳＯ）心肌损伤模型上，观察了内皮素（ＥＴ）及降钙素基因相关肽（ＣＧＲＰ）对ＩＳＯ损伤心肌作用的影响．结果表明：ＥＴ明显加重ＩＳＯ对心肌的损伤，ＣＧＲＰ则能减轻ＩＳＯ对心肌的损伤及ＩＳＯ与ＥＴ对心肌的协同损伤．提示心肌病理情况下，ＥＴ是一种促损伤因素，而ＣＧＲＰ是抗损伤因素．
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| 关 键 词： | 内皮素，降钙素基因相关肽，异丙肾上腺素，心肌 |
The Effect of Endothelin and Calcitonin Gene-Related Peptide on Isoprenaline-induced Damage of Rat Myocardium |
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| Dunyong Tan,Jifeng Zhang,Aihua Fu,et al.. The Effect of Endothelin and Calcitonin Gene-Related Peptide on Isoprenaline-induced Damage of Rat Myocardium[J]. Journal of Cardiovascular and Pulmonary Diseases, 1994, 13(1): 43-44 |
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| Authors: | Dunyong Tan Jifeng Zhang Aihua Fu et al. |
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| Abstract: | The effect of endothelin (ET) and calcitonin gene related peptide(CGRP)on the isoprenaline(ISO)-induced damage of rat myocardium was investigated.It was found that administration of ET greatly aggravated,but CGRP alleviated the myocardial damage induced by ISO,and that the aggravating effect of ET was obviously antagonized by infusion of CGRP.The results suggested that CGRP could be available in treating cardio and cerebral-vascular diseases, in which ET is involved. |
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| Keywords: | Endothelin Calcitonin gene-related peptide Isoprenaline Myocardium |
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